产品描述:
Dihydrocoumarin is a coumarin that has been found in M. officinalis and has enzyme inhibitory activity.{58675,58676} It inhibits the activities of sirtuin 1 (SIRT1) and SIRT2 (IC50s = 208 and 295 µM, respectively, for the human enzymes). Unlike coumarin, dietary administration of dihydrocoumarin (0.76%) does not induce hepatocyte vacuolation, bile duct hyperplasia, or cholangiofibrosis.{58676} Formulations containing dihydrocoumarin have been used as flavoring agents.