产品描述:
MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a Ki value of 1.3 µM.{32858,32859} It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 µM, respectively.{32858} MY-5445 has been shown to relax intact strips of rat aorta with an EC50 value of 4 µM.{32858}