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(R,S)-Anatabine (tartrate)
品牌： Cayman
产品货号： 15132-50 mg
规格： 50 mg

报价：
折后价：

数量： - +
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  • 产品名称:
    (R,S)-Anatabine (tartrate)
  • 别名:
    (±)-Anatabine
  • 产品描述:
    (R,S)-Anatabine is an alkaloid that has been found as a minor component in tobacco (Nicotiana).{20193} It is an agonist of α4β2 and α6/α3β2β4 subunit-containing nicotinic acetylcholine receptors (nAChRs; EC50s = 6.1 and 3.6 µM, respectively). It is selective for α4β2 and α6/α3β2β4 subunit-containing nAChRs over α3β4 subunit-containing nAChRs and α7 nAChRs (EC50s = 70.6 and 158.5 µM, respectively).{69082} (R,S)-Anatabine stimulates dopamine, but not norepinephrine, release from isolated rat brain synaptosomes (EC50s = 1.76 and >100 µM, respectively). It increases the time spent at the top of the tank in a novel tank test, indicating anxiolytic-like activity, in zebrafish when used at a concentration of 10 mg/L. (R,S)-Anatabine (0.05 mg/ml in the drinking water) decreases disease severity in a mouse model of moderate, but not low or severe, experimental autoimmune thyroiditis induced by immunization with thyroglobulin, complete Freund's adjuvant (CFA), and M. tuberculosis.{69083} It decreases food and nicotine self-administration in monkeys (ED50s = 2.085 and 0.854 mg/kg, respectively).{69084} (R,S)-Anatabine has been used as a biomarker of tobacco use.{20195,20196}
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    310.3
  • 产品形式:
    A crystalline solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥98%
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  • 分子式:
    C10H12O2 • C4H6O6
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