产品描述:
ML-356 is an inhibitor of the thioesterase domain of fatty acid synthase (FASN-TE; IC50 = 334 nM).{32731} It is selective for FASN over a number of other human thioesterases expressed in tumor cells, and selective for FASN-TE over its most closely related human homolog, ACOT4.{32731} In cells, ML-356 has been shown to block the biosynthesis of palmitate, the end product of FASN.{32731}