产品描述:
UNC926 is an antagonist of the MBT domain-containing methyl-lysine reader proteins L3MBTL1, L3MBTL3, and L3MBTL4.{48422} It inhibits methyl-lysine histone peptide substrate binding of L3MBTL1, L3MBTL3, and L3MBTL4 (IC50s =3.9, 3.2, and 15.6 μM, respectively) selectively over MBT domain-containing MBTD1 and SFMBT1 and chromo domain-containing CBX7 (IC50s = >30 μM).