产品描述:
Tiaprofenic acid is a COX inhibitor and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic activities.{45285} It inhibits synthesis of prostaglandin E2 (PGE2; Item No. 14010) and PGF2α (Item Nos. 16010 | 16020) from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in bovine seminal vesicle microsomes and inhibits thromboxane B2 (TXB2; Item No. 19030) formation in human umbilical cord arteries bathed in clotting human blood (IC50 = 0.71 μM).{45286,45285} Tiaprofenic acid has anti-inflammatory activity in rat models of carrageenan-induced edema and adjuvant-induced arthritis and has analgesic activity in acetic acid- or phenylquinone-induced writhing tests in rodents.{45285}