产品描述:
Verubecestat is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and BACE2 (Kis = 2.2 and 0.38 nM, respectively).{32906} It has a high selectivity for BACE1 and BACE2 over closely related aspartyl proteases, including cathepsin D.{32906} Formulations containing verubecestat profoundly lower levels of β-amyloid proteins in brain and cerebrospinal fluid (CSF) in rats and nonhuman primates and in CSF in humans.{32906,33512}