产品描述:
S63845 is an inhibitor of myeloid cell leukemia 1 (Mcl-1; Ki = 0.19 nM), a pro-survival protein that is overexpressed in many cancers.{32698} It induces cell death in multiple myeloma, leukemia, and lymphoma cell lines (IC50s = via mitochondrial apoptosis. S63845 acts synergistically with trametinib (Item No. 16292), lapatinib (Item No. 11493), PLX4032 (Item No. 10618), and erlotinib (Item No. 10483) to reduce proliferation of SK-MEL-2, BT474, A2058, and PC9 cells, respectively. S63845 (6.25-25 mg/kg) reduces tumor volume in an MV4-11 acute myeloid leukemia mouse xenograft model in a dose-dependent manner.