产品描述:
POM 1 is a polyoxometalate that inhibits ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) 1 and 3 with Ki values of 2.58 and 3.26 µM, respectively.{33011} It demonstrates 10-fold lower inhibitory activity for NTPDase 2 (Ki = 28.8 µM) and does not inhibit P2Y12 receptors (Ki > 10 µM).{33011} Inhibition of ecto-NTPDases that are capable of hydrolyzing nucleoside tri- and diphosphates (i.e., ATP, ADP, UTP, or UDP) can result in a potentiation of purinergic signaling due to an increase in the extracellular nucleotide concentrations. This subtype-selective NTPase inhibitor has been used to investigate the mechanisms of purinergic signaling.{33012}