产品描述:
EFdA is a nucleoside reverse transcriptase inhibitor (NRTI).{58463} It inhibits HIV-1 reverse transcriptase via multiple mechanisms. EFdA inhibits replication of the HIV-1 strain HIV-1 IIIb, the laboratory isolate HIV NL4-3, and the clinical isolate HIV-2 EHO in MT-4 cells (EC50s = 73, 50, and 98 pM, respectively).{58464} It is also active against drug-resistant HIV with EC50 values ranging from 0.23 to 23 nM in a multinuclear activation of a galactosidase indicator (MAGI) assay.{58465} EFdA (1 and 10 mg/kg per day) prevents infection with HIV JR-CSF in humanized mice.{58466}