产品描述:
Stiripentol-d9 is intended for use as an internal standard for the quantification of stiripentol (Item No. 17781) by GC- or LC-MS. Stiripentol is a third-generation antiepileptic compound.{28852} It is a positive allosteric modulator of GABAA receptors, potentiating GABA-mediated activation to a greater extent in receptors expressing α3 subunits and to a lower extent in those containing β1 or ε subunits.{48495} It also inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices.{28852,48496} Stiripentol (500 µM) inhibits lactate dehydrogenase (LDH), blocking both lactate-to-pyruvate and pyruvate-to-lactate conversions by human LDH1 and LDH5.{28811} Formulations containing stiripentol have been used in the adjunctive treatment of seizures associated with Dravet syndrome.