产品描述:
GSK3484862 is an inhibitor of DNA methyltransferase 1 (DNMT1; IC50 = 0.23 µM).{67438} It is selective for DNMT1 over DNMT3A/3L and DNMT3B/3L (IC50s = >50 µM for both). GSK3484862 (100-1,000 nM) inhibits the growth of MV4-11 leukemia cells. It also decreases promoter DNA methylation in MV4-11 cells.