产品描述:
Opicapone is a peripherally selective inhibitor of catechol-O-methyltransferase (COMT).{62240} It inhibits COMT activity in rat liver, but not brain, homogenates (ED50 = 1.05 mg/kg). Opicapone (3 mg/kg) increases plasma levels of L-DOPA (Item No. 13248) and reduces plasma levels of 3-O-methyl-DOPA (3-OMD) when administered in combination with benserazide (Item No. 20298) and L-DOPA.{62241} Formulations containing opicapone have been used as adjuvants in the treatment of “off” episodes associated with Parkinson’s disease.