产品描述:
8-Geranyloxypsoralen is a prenylated furanocoumarin that has been found in C. limon and has diverse biological activities.{9551,69445,21872} It inhibits the cytochrome P450 (CYP) isoform CYP3A4 and β-secretase 1 (BACE1; IC50s = 3.93 and 20.4 µM, respectively).{69445,21872} 8-Geranyloxypsoralen (50 µM) inhibits Epstein-Barr virus activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA; Item No. 10008014) in infected Raji B-lymphoblastoid cells, TPA-induced superoxide generation in HL-60 leukemia cells, and LPS- and IFN-γ-induced nitric oxide (NO) generation in RAW 264.7 macrophages.{9551}