产品描述:
Nanaomycin A is a quinone bacterial metabolite originally isolated from Streptomyces that has antimicrobial activity.{45188} It inhibits the growth of a variety of bacteria (MICs = P. falciparum (IC80 = 0.033 µM).{45188,57310} Nanaomycin A is a selective DNA methyltransferase 3B (DNMT3B) inhibitor that inhibits proliferation of HCT116, A549, and HL-60 cancer cells (IC50s = 0.4, 4.1, and 0.8 µM, respectively).{57311} Nanaomycin A promotes the differentiation of human induced pluripotent stem (iPS) cells into hepatoblasts at the definitive endoderm cell-to-hepatoblast stage, but not the iPS cell-to-definitive endoderm cell stage, when used at a concentration of 1 µM.{57312}