产品描述:
CP 346,086 is an inhibitor of microsomal triglyceride transfer protein (MTTP; IC50 = 2 nM).{69476} It inhibits apolipoprotein B (ApoB) and triglyceride secretion in HepG2 cells (IC50 = 2.6 nM for both). CP 346,086 (10 mg/kg) lowers plasma triglyceride levels, as well as plasma total, VLDL, and LDL cholesterol levels in rats.