产品描述:
DPCPX is an adenosine A1 receptor antagonist (Ki = 0.3 nM).{66536} It is selective for the adenosine A1 receptor over the adenosine A2 receptor (Ki = 340 nM). DPCPX (0.03 and 1 µM) increases the force of contractions in isolated guinea pig left auricles and inhibits decreases in contraction forces induced by the adenosine receptor agonists (–)-N6-phenylisopropyladenosine (PIA) or 5'-N-ethylcarboxamidoadenosine (NECA; Item No. 21420) in isolated guinea pig papillary muscles (pA2s = 9.3 and 9, respectively).{66537} It reverses cardiac arrest induced by adenosine, the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA; Item No. 21448), or the acetylcholine receptor agonist carbachol (carbamoylcholine; Item No. 14486) in isolated rat atrium.{66538} DPCPX (2 and 4 mg/kg) decreases immobility time in the forced swim test and tail suspension test in mice.{66539}