产品描述:
TK05 is an inhibitor of leukotriene C4 (LTC4) synthase (IC50 = 95 nM).{31499} It is selective for LTC4 synthase over microsomal prostaglandin E synthase-1 (mPGES-1), microsomal glutathione S-transferase 2 (GST2), and 5-lipoxygenase (5-LO) at 10 µM. TK05 (1 µM) inhibits LTC4 synthase in Mono-Mac-6 leukemia cells and isolated human eosinophils, monocytes, and platelets but not cord blood-derived mast cells. In vivo, TK05 (0.12 and 6 mg/kg) prevents zymosan A-induced increases in peritoneal fluid levels of LTE4 and LTB4 in mice.