产品描述:
Cnicin is a germacranolide sesquiterpene lactone that has been found in Centaurea and has diverse biological activities.{65946,65947,65948} It irreversibly inhibits the UDP-N-acetylglucosamine (UDP-GlcNAc) 1-carboxyvinyltransferase MurA (IC50s = 16.7 and 10.3 for the E. coli and P. aeruginosa enzymes, respectively) and is active against B. cereus and M. flavus (MICs = 1.25 and 5 µg/ml, respectively).{65946,65947} Cnicin inhibits the growth of MCF-7 breast and OVCAR-3 ovarian cancer cells (GI50s = 37.8 and 37.4 µM, respectively).{65947} It reduces snake venom-induced paw edema in rats when administered at doses ranging from 2.5 to 10 mg/kg.{65948}