产品描述:
Strophanthidin is a cardenolide that has been found in A. schimperi and has diverse biological activities.{41362,42765,25457,65940} It is an inhibitor of N-acetyltransferase (IC50 = ~1.2 µM).{41362} Strophanthidin (1 µM) reduces maximal Na+/K+-ATPase pump activity and cell attachment and increases cell death in MDCK-C7 cells.{42765} It decreases the levels of steroid receptor coactivator 3 (SRC-3) in MCF-7 breast cancer cells when used at a concentration of 500 nM.{25457} Strophanthidin (50 µM) increases calcium efflux and sarcoplasmic reticulum calcium levels in a voltage-clamp assay using isolated and perfused guinea pig hearts.{65940}