产品描述:
ARQ 531 is an inhibitor of Bruton's tyrosine kinase (BTK; IC50 = 0.85 nM).{51664} It reduces the viability of, and inhibits BTK autophosphorylation in, OCI-AML-2 acute myeloid leukemia (AML) cells when used at concentrations of 0.3 and 1 µM.{51663} In vivo, ARQ 531 (75 mg/kg) reduces tumor growth in an SU-DHL-4 B cell lymphoma mouse xenograft model.{51664}