产品描述:
ML-241 is an ATP-competitive inhibitor of the ATPase p97 (IC50 = 0.11 µM) that is selective for the D2 domain of p97.{28269,28270} It disrupts the endoplasmic reticulum-associated degradation (ERAD) pathway, preventing the degradation of p97-dependent proteasome substrates in a reporter assay using HeLa cells (IC50 = 3.5 µM) and inducing the accumulation of ubiquitin conjugates in the nuclear plus membrane and cytosolic compartments of SW403 colon cancer cells when used at concentrations of 5 and 10 µM.{28269} Unlike the p97 inhibitor ML-240, ML-241 does not induce autophagy or apoptosis in, or inhibit the proliferation of, HCT15 and SW403 cancer cells.