产品描述:
SEN-177 is a glutaminyl cyclase inhibitor (IC50 = 53 nM).{66671} It reduces polyglutamine aggregation in HeLa cells expressing EGFP-HTT-Q74, an in vitro model of Huntington’s disease when used at concentrations of 12.5 and 25 µM.{66672} SEN-177 (50 µM) reduces polyglutamine aggregation in primary mouse neurons expressing EGFP-Q80.