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PF-06651600
品牌: Cayman
产品货号: 21054-100 mg
规格: 100 mg

报价:
折后价:

数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    PF-06651600
  • 别名:
    Ritlecitinib
  • 产品描述:
    PF-06651600 is a covalent inhibitor of JAK3 (IC50 = 33.1 nM).{69674} It is selective for JAK3 over JAK1, JAK2, and tyrosine kinase 2 (TYK2; IC50s = >10,000 for all) and a panel of 304 other kinases at 1 µM. PF-06651600 inhibits STAT5, STAT6, and STAT3 phosphorylation induced by IL-2, IL-4, or IL-21, respectively, in isolated human lymphocytes (IC50s = 244, 340, and 350 nM, respectively). It inhibits T cell differentiation into the T helper cells Th1 and Th17 in a T cell differentiation assay (IC50s = 30 and 167 nM, respectively). PF-06651600 (3, 10, or 30 mg/kg) reduces paw swelling in a rat model of adjuvant-induced arthritis. It also decreases disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) when administered at doses of 30 or 100 mg/kg. Formulations containing PF-06651600 have been used in the treatment of severe alopecia in adults and adolescents.
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  • 阳性对照:
  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    285.3
  • 产品形式:
    A solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥95%
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  • CAS号:
    1792180-81-4
  • 分子式:
    C15H19N5O
  • 溶解度:
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