产品描述:
GNF-362 is an inositol triphosphate 3 kinase (ITPK) inhibitor (IC50s = 20, 9, and 19 nM for ITPKA, ITPKB, and ITPKC, respectively).{67649} It induces calcium influx in isolated mouse splenocytes (EC50 = 12 nM). In vivo, GNF-362 (10 and 25 mg/kg) reduces the number of thymic CD4+ T cells in mice. It also reduces inflammatory cell infiltration, joint erosion, and proteoglycan loss, in a rat model of antigen-induced arthritis when administered at a dose of 20 mg/kg.