产品描述:
Z-L-Phe-CMK is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (Mpro), also known as 3C-like protease (3CLpro; Ki = 306 nM).{55432} It is selective for SARS-CoV Mpro over calpain, trypsin, and thrombin (Kis = 10, >100, and >100 µM, respectively). Z-L-Phe-CMK (20 µM) also inhibits the protein-protein interaction between p53 and MDM2 in U2OS osteosarcoma cells.{67196} It has been used as a building block in the synthesis of HIV protease inhibitors.{67195}