产品描述:
KYP-2047 is an inhibitor of prolyl endopeptidase (Ki = 0.02 nM for the porcine enzyme).{51727} It inhibits hydrogen peroxide-induced aggregation of α-synuclein in SH-SY5Y cells expressing wild-type, α-synucleinA30P, or α-synucleinA53T in in vitro models of Parkinson’s disease when used at a concentration of 1 µM.{51728} KYP-2047 (10 µM) decreases lipid peroxidation and the production of reactive oxygen species (ROS) induced by palmitic acid (Item No. 10006627) in HepG2 cells.{51729} It decreases ileal and pulmonary edema and pulmonary fibrosis in a mouse model of acute lung injury induced by intestinal ischemia-reperfusion when administered at a dose of 2.5 mg/kg.{51730} KYP-2047 (2.5 mg/kg) reduces tumor volume and intratumoral levels of Vegf and Cd34, markers of angiogenesis, in a U87 glioblastoma mouse xenograft model.{51726}