产品描述:
Disulfiram is a copper chelator and an irreversible inhibitor of aldehyde dehydrogenase (ALDH; IC50 = 0.1 mM).{25186} It increases the production of reactive oxygen species (ROS) when used at a concentration of 250 nM, as well as increases NF-κB protein levels and reduces neurosphere formation in U87MG glioblastoma multiforme cells at 1 µM.{25187} Disulfiram (50 mg/kg per day) decreases tumor growth, inhibits proteasome activity, and induces apoptosis in an MDA-MB-231 breast cancer mouse xenograft model.{25183} Formulations containing disulfiram have been used in the treatment of alcohol dependence.