产品描述:
Auranofin is a gold-thiol complex with diverse biological activities.{25302,25305,61148} It inhibits thioredoxin reductase (IC50 = 0.2 µM), increases oxidation of mitochondrial peroxiredoxin 3 (PRDX3), and induces apoptosis in Jurkat T cells.{25302} Auranofin reduces the production of IL-6 and activation of JAK1 and JAK2, as well as inhibits nuclear translocation of NF-kB, in primary human synoviocytes.{25305} It is active against P. falciparum and S. mansoni in vitro when used at concentrations ranging from 1 to 10 µM. In vivo, auranofin (2 mg/kg per day) reduces the number of peripheral blood mononuclear cells (PBMCs) containing viral DNA and delays viral rebound in macaques infected with the mac251 strain of simian immunodeficiency virus (SIV).{61148} Auranofin (0.5 µM) synergizes with buthionine sulfoxime (BSO) to decrease glutathione peroxidase 4 (GPX4) levels, increase intracellular accumulation of reactive oxygen species (ROS), and induce ferroptosis in Huh7 and HepG2 hepatocellular carcinoma cells.{60465}