产品描述:
PTP inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)).{31401} PTP inhibitor II binds with lower affinity than PTP Inhibitor I (Item No. 19766) with Ki values of 128 and 43 μM, respectively.{31401} SHP-1 has known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.{31658}