产品描述:
GSK329 is an inhibitor of cardiac troponin I-interacting kinase (TNNI3K; IC50 = 10 nM) and a derivative of the multi-kinase inhibitor sorafenib (Item Nos. 10009644 | 35612).{68721} It is selective for TNNI3K over VEGFR2, p38α, and B-RAF (IC50s = 400, 800, and >2,000 nM, respectively). In vivo, GSK329 (2.75 mg/kg) reduces superoxide levels in isolated left ventricular tissues and infarct size in a mouse model of myocardial ischemia-reperfusion injury induced by left anterior descending (LAD) coronary artery occlusion.{68722}