产品描述:
1A-116 is an inhibitor of Rac1 (IC50 = 4 µM).{51743} It reduces the secretion of chemokine (C-X-C motif) ligand 5 (CXCL5), CXCL10, hepatocyte growth factor (HGF), chemokine (C-C motif) ligand 2 (CCL2), and matrix metalloproteinase-2 (MMP-2) from patient-derived acute myeloid leukemia (AML) cells when used at a concentration of 20 µM.{51744} 1A-116 (20 µM) inhibits the proliferation and migration of, and induces apoptosis in, LN-229 glioblastoma cells at 10 hours, but not 23 hours, post-synchronization.{51745} In vivo, IA-116 (3 mg/kg per day) decreases the number of lung nodules and macronodules, as well as total lung weight, in a F3II murine breast cancer model of lung tumor formation.{51743} It also inhibits the asexual replication of the P. falciparum strains D10 and W2 (IC50s = 3.21 and 6.89 µM, respectively) and sexual replication in P. falciparum 3D7 immature and mature gametocytes (IC50s = 78.13 and 56.64 µM, respectively).{51746}