产品描述:
SRI-37330 is an inhibitor of thioredoxin-interacting protein (TXNIP).{55417} It inhibits the expression of Txnip mRNA in INS-1 rat insulinoma cells (IC50 = 0.64 µM) and decreases Txnip protein levels in the same cells in a concentration-dependent manner. SRI-37330 (10 µM) inhibits LPS-induced pyroptosis in A549 cells overexpressing fat mass and obesity-associated (FTO) protein in an in vitro model of acute lung injury.{66710} In vivo, SRI-37330 (100 mg/kg) reduces non-fasting and fasting blood glucose levels, serum glucagon levels, and hepatic glucose production in wild-type and db/db mice.{55417} It also decreases non-fasting blood glucose levels, urinary glucose levels, and serum triglyceride levels in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).