产品描述:
TP-0472993 is an inhibitor of the cytochrome P450 (CYP) isoforms CYP4A11 and CYP4F2 (IC50s = 140 and 40 nM, respectively).{67824} It is selective for CYP4A11 and CYP4F2 over a panel of eight additional CYPs at 10 µM. TP-0472993 inhibits 20-HETE (Item No. 90030) production in rat renal microsomes (IC50 = 347 nM). In vivo, TP-0472993 (0.03-1 mg/kg) inhibits 20-HETE production in rats. It also reduces renal fibrosis and IL-1β and TNF-α levels in a mouse model of folic acid-induced nephropathy and a mouse model of unilateral ureteral obstruction-induced neuropathy when administered at a dose of 3 mg/kg.{67825}