产品描述:
Hydroxyfasudil is an inhibitor of ROCK1 and ROCK2 (IC50s = 0.15 and 0.57 µM, respectively) and an active metabolite of the Rho-associated kinase (ROCK) inhibitor HA-1077 (fasudil; Item No. 10010559).{72376} In vivo, hydroxyfasudil (3 and 10 mg/kg) decreases blood viscosity and prevents cerebral vasospasm in a canine model of subarachnoid hemorrhage.{72377} Hydroxyfasudil also reverses hypertension-associated dysfunction of relaxation induced by nitric oxide in corpus cavernosum smooth muscle in spontaneously hypertensive rats.{72378}