产品描述:
Tanzawaic acid B is a fungal metabolite that has been found in Penicillium and has diverse biological activities.{49857,49858} It inhibits protein tyrosine phosphatase 1B (PTP1B) in a cell-free assay (IC50 = 8.2 µM) and LPS-induced production of nitric oxide (NO) in BV-2 microglia (IC50 = 42.5 µM).{49857} Tanzawaic acid B is active against chloroquine-resistant and chloroquine-sensitive P. falciparum strains (IC50s = 78.5 and 79.2 µM, respectively).{49858}