产品描述:
Takeda-103A is an inhibitor of G protein-coupled receptor kinase 2 (GRK2).{51784} It selectively inhibits phosphorylation of bovine rod outer segments by GRK2 (IC50 = 54 nM) over phosphorylation by GRK1 and GRK5 at concentrations up to 125 µM. Takeda-103A also inhibits phosphorylation of bovine rod outer segments by GRK2 containing various mutations, including GRK2L271M, GRK2Y206S, GRK2I197L, and GRK2L235G (IC50s = 24, 55, 106, and 180 nM, respectively).