产品描述:
AH 10639 is an amine-modified pteridine.{51786} It selectively inhibits T. gondii dihydrofolate reductase (DHFR; IC50 = 0.033 µM) over DHFR from the pathogenic yeast P. carinii and rat liver (IC50s = 0.2 and 1.1 µM, respectively). AH 10639 reduces T. gondii replication in T. gondii-infected MDBK bovine kidney cells with a mean significant inhibitory (MSI) concentration value of 1 µM and inhibits the uptake of para-aminobenzoic acid, a folate precursor, by P. carinii (IC50 = 16.2 µM). It increases survival in V. cholera-infected mice when administered at a dose of 500 mg/kg.{51787} AH 10639 reduces energy loss and increases thermal stability and power conversion efficiency, as well as improves interfacial contacts, when applied to the fullerene/cathode interface in inverted perovskite solar cells.{51785}