产品描述:
MBP146-78 is an inhibitor of parasitic cGMP-dependent protein kinases (PKGs; IC50s = 1.9 and 1 nM for the E. tenella and T. gondii enzymes, respectively).{67818} It inhibits P. berghei sporozoite development into liver-stage parasites in HepG2 cells in a concentration-dependent manner.{67819} MBP146-78 (50 mg/kg) prevents P. yoelii liver infection in P. yoelii-infected mice. It increases survival time in P. berghei-infected mice when administered at a dose of 50 mg/kg twice per day for eight days.{67818} MBP146-78 (50 mg/kg two times per day) increases survival in T. gondii-infected mice and prevents secondary reinfection in the same mice.{67820}