产品描述:
UNC0321 is an inhibitor of the histone methyltransferases G9a and G9a-like protein (GLP; IC50s = 9 and 15 nM, respectively).{18337} It is selective for G9a and GLP over SET domain-containing protein 7 (SET7), SET8, protein arginine methyltransferase 3 (PRMT3), and jumonji domain-containing 2E (JMJD2E; IC50s = >10,000 nM for all). UNC0321 decreases the levels of dimethylated lysine 9 on histone H3 (H3K9me2) in MDA-MB-231 cells (IC50 = 11 µM) without inducing cytotoxicity (EC50 = >40 µM).{19978}