产品描述:
TP-060 is an inhibitor of UDP-glucose ceramide glucosyltransferase (IC50 = 0.031 µM).{51775} It is selective for UDP-glucose ceramide glucosyltransferase over human ether-a-go-go (hERG) at 10 µM but also inhibits serotonin receptors (5-HT; IC50 = 0.31 µM). In vivo, TP-060 (30 mg/kg per day) decreases the cerebral cortex and serum levels of glucosylceramide and glucosylsphingosine in a Gba D409V transgenic mouse model of Gaucher disease.{51774}