产品描述:
8RK64 is a covalent inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1; IC50 = 0.32 µM) and a click chemistry reagent.{51788} It is selective for UCH-L1 over UCH-L3 and UCH-L5 (IC50s = 216 and >1,000 µM, respectively). 8RK64 has been linked to fluorophores containing alkyne groups via copper(I)-catalyzed azide/alkyne cycloaddition (CuAAC) and used to visualize UCH-L1 activity in cells.