产品描述:
11α-Hydroxyprogesterone (11α-OHP) is an inhibitor of 11β-hydroxysteroid dehydrogenase (IC50s = 0.63 and 0.4 µM for recombinant human 11β-HSD1 and 11β-HSD2, respectively) and a derivative of the endogenous hormone progesterone (Item No. 15876).{66050,67748} 11α-OHP (10, 100, and 500 µg/animal) reduces urinary sodium excretion in male adrenalectomized rats when administered in combination with the steroid hormone corticosterone (Item No. 16063) but not when administered alone.{66050} It potentiates corticosterone-induced increases in urinary potassium excretion in the same model but has no effect on urinary potassium excretion when administered alone. 11α-OHP increases blood pressure in rats when administered subcutaneously at a rate of 10 µg/hour, an effect that can be blocked by adrenalectomy or reduced by co-administration of the mineralocorticoid receptor antagonist RU-28318.{66051} It has been used as a precursor in the synthesis of various steroids, including 11β-aminoprogesterone and derivatives of 11β-aminoprogesterone and 5ζ-pregnanolone.{67748,67749}