产品描述:
Eribulin is an inhibitor of microtubule assembly and a derivative of the marine sponge macrolide halichondrin B.{66795} It inhibits the proliferation of U937 human lymphoma cells, as well as induces cell cycle arrest at the G2/M phase and, subsequently, apoptosis in the same cells when used at a concentration of 100 nM.{66796} Eribulin (1.5 mg/kg per week) reduces tumor growth in a patient-derived xenograft (PDX) mouse model of cutaneous squamous cell carcinoma.{66797} It also reduces tumor growth and increases survival in an intracerebral U87MG mouse xenograft model of glioblastoma when administered at a dose of 0.5 mg/kg three times per week.{66798} Formulations containing eribulin have been used in the treatment of metastatic breast cancer.