产品描述:
Methylisothiazolinone (MI) is an isothiazolinone-derived biocide.{30030,37117} It is active against Gram-positive and Gram-negative bacteria, as well as fungi, when used in combination with methylchloroisothiazolinone (MCI) with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively.{37117} Methylisothiazolinone (50 µM) also inhibits c-Src autophosphorylation in a cell-free assay.{37116} It reduces cell viability percentage in isolated embryonic rat cortical neurons when used at a concentration of 3 µM and decreases neurite length at 1 µM. MI, alone and as a mixture with MCI, can elicit contact sensitization.{30031} Formulations containing methylisothiazolinone have been used in the control of bacteria, fungi, and algae in residential use and industry, as well as a preservative in personal care products.