产品描述:
PF-06826647 is an inhibitor of tyrosine kinase 2 (TYK2; IC50 = 15 nM).{67650} It is selective for TYK2 over JAK1, JAK2, and JAK3 (IC50s = 383, 74, and >10,000 nM, respectively). PF-06826647 inhibits IL-12-induced phosphorylation of STAT4 in isolated human whole blood (IC50 = 14 nM). In vivo, PF-06826647 (3-30 mg/kg, p.o.) reduces ear edema in a mouse model of skin inflammation induced by the toll-like receptor 7 (TLR7) agonist imiquimod (Item No. 14956).