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Lucitanib (hydrochloride)
品牌： Cayman
产品货号： 37711-10 mg
规格： 10 mg

报价：
折后价：

数量： - +
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  • 产品名称:
    Lucitanib (hydrochloride)
  • 别名:
    AL 3810|E-3810
  • 产品描述:
    Lucitanib is a dual inhibitor of VEGFR and FGFR that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50s = 7, 25, and 10 nM, respectively) and FGFR1 and FGFR2 (IC50s = 17.5 and 82.5 nM, respectively).{66808} It is selective for these receptors over FGFR3 and FGFR4 (IC50s = 237.5 and >1,000 nM, respectively), as well as the PDGFR family members c-Kit, PDGFRα, and PDGFRβ (IC50s = 456, 175, and 525 nM, respectively), but does inhibit FMS, also known as CSF-1 receptor tyrosine kinase (IC50 = 5 nM). Lucitanib inhibits the proliferation of human umbilical vein endothelial cells (HUVECs) induced by VEGF or basic FGF (bFGF; IC50s = 40 and 50 nM, respectively) but inhibits the proliferation of A2780 ovarian, A498 renal, and SN12KI renal cancer cells only at higher concentrations (IC50s = 27.7, 19.6, and 12.79 µM, respectively). It reduces tumor growth in HT-29 colon and A2780 ovarian cancer mouse xenograft models, as well as in RXF 393, A498, and SKN12I renal cancer mouse xenograft models in a dose-dependent manner. It also completely inhibits bFGF-induced angiogenesis in a Matrigel™ plug assay in mice when administered at a dose of 20 mg/kg.
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  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    516.4
  • 产品形式:
    A crystalline solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥95%
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  • CAS号:
    2108875-91-6
  • 分子式:
    C26H25N3O4 • 2HCl
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