产品描述:
SGC6870 is an inhibitor of protein arginine methyltransferase 6 (PRMT6; IC50 = 77 nM).{51801} It is selective for PRMT6 over a panel of 76 methyltransferases, G protein-coupled receptors (GPCRs), ion channels, receptors, and other enzymes at 1 µM. SGC6870 decreases the levels of dimethylated arginine 2 on histone 3 (H3R2me2) and dimethylated arginine 3 on histone 4 (H4R3me2) in HEK293T cells (IC50s = 0.9 and 0.6 µM, respectively). See the Structural Genomics Consortium (SGC) website for more information.