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产品名称:
Verrucarin A
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别名:
Muconomycin-A; 379-Y; Glutinosin-I; Myrothecin-I; NSC-126728
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产品描述:
Modulates Amyloid-beta production in Alzheimer’s neurons
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同种型:
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阳性对照:
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保存温度:
-20ºC
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运输温度:
Shipped Ambient
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细胞定位:
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预期分子量:
502.6
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产品形式:
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存储溶液:
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有效期:
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产地:
加拿大
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外观:
Off-white powder
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生产商:
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功能与背景:
Verrucarin A is a macrocyclic trichothecene mycotoxin from Myrothecium sp. It is being investigated as it modulates amyloid-beta production in Alzheimer's patients neurons (1). It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its expression (2). It is cytotoxic to multiple types of cancer cells at low nM concentrations (IC50=4.9 nM for HepG2 cells) but not toward normal liver cells (2,3). It enhances TNFα-induced (4) and TRAIL-induced apoptosis (5). It reduces phosphorylation of IREα and inhibits tunicamycin-induced ER stress in FaO rat liver cells (6).
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产品特点:
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纯度:
>98% (HPLC); NMR (Conforms)
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来源:
Synthetic
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Accession #:
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CAS号:
3148-09-2
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分子式:
C27H34O9
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溶解度:
May be dissolved in DMSO (25 mg/ml)
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PubChem CID: