产品描述:
Z-FF-FMK is an inhibitor of cathepsin B (Ki = 2.7 nM).{68823} It inhibits cell division, cell cycle progression, DNA replication, and chromosome decondensation in isolated T. niger fertilized embryos when used at a concentration of 100 µM.{68824} Z-FF-FMK (10 µM) prevents increases in cathepsin L activity induced by amyloid-β (1-40) (Aβ40), as well as prevents Aβ40-induced apoptosis, DNA fragmentation, and increases in cleaved poly(ADP-ribose) polymerase (PARP) levels, in primary rat cortical neurons.{68825} In vivo, Z-FF-FMK (5 nmol/animal) inhibits quinolinic acid-induced nuclear translocation of NF-κB, as well as inhibits quinolinic acid-induced increases in phosphorylated IκBα and IKKα levels, in the unilateral striatum in rats.{68826}